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Offres d'emploi - chercheur

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  • The successful candidate will work as a Senior Scientist in our Cell Therapy Group within the department of Preclinical, Pharmacology and Safety (PPS) and will report to the head of the PPS team. She/he will lead one or two people and contribute to the creation and advancement of CAR-Treg-based cell therapy for applications in autoimmune diseases. The role will consist of managing direct reports, designing assays, data analysis, troubleshooting assays, and participating in group and departmental meetings. Sangamo Therapeutics’ differentiating approach to CAR-Treg therapy includes the development and characterization of autoimmune models regarding safety and efficacy and managing outsourced activities. The position requires adaptability, creativity, good written and verbal communication skills in English, and a capacity for constant innovation in pursuit of company goals. The environment is exciting and fast-paced and offers the opportunity to work and publish at the cutting edge of genome editi...

  • Part of the Process Analytics & Mass Spectrometry team. Direct report to the Senior Manager/Lab Head.

    - Participate in the planning and execution of all requests from different teams according to project timelines and budget;
    - Responsible for all aspects of method development (mainly high-throughput methods), sample preparation, data acquisition, data analysis and data interpretation using software platforms
    - Author, review and edit internal protocols / reports, documents, internal presentations;
    - Use the most appropriate experimental design (including DoE) and problem-solving methods to define the analytical corridor;
    - Attend cross functional meetings;
    - Contribute to method transfer between labs, according to the project
    - Escalate issues in a timely fashion (technical);
    - Operate as part of a cross-functional project team;
    - Completion and peer review of electronic laboratory notebook;
    - Prepare and deliver draft...

  • A post-doctoral position is available in the “translational research in neurological disorder lab” in IHU Imagine for the DYSCLO project studying Chloride Deregulation in Focal Cortical Dysplasia.

    Scientific project
    The DYSCLO project, recently funded by ANR jc-jc aims at unraveling the mechanisms underlying epileptogenicity in pediatric focal cortical dysplasia (FCD).

    By studying ex vivo surgical specimens our team recently showed a paradoxical GABAergic depolarization, secondary to chloride cotransporters deregulation in FCD.

    How this functional disorder is related to the genomic defect in the mTOR pathway is still to decipher and is the milestone of this project.

    We will address this by the combination of in vitro electrophysiology with multiomics approaches. First, a precise mapping of epileptic activities on the cortical slice with micro electrode arrays will allow us to delineate the epileptic focus ...

  • Two research positions (for a post-doctoral scientist and a technician/Assistant Ingénieur) are available for 16 months-18 months in the first instance (international funding led by CARB-X/Boston University), in Pr. Jean-Michel Sallenave’s laboratory (see address below) in the INSERM Unit 1152 (Physiopathologie et Epidémiologie des maladies respiratoires, Faculty of Medicine, Hôpital Bichat). Starting date as soon as possible.

    The project aims at studying host-Pseudomonas aeruginosa molecular and cellular interactions during inflammation. A particular emphasis will be put on the testing of potential therapeutic agents in vitro and in vivo.

    The succesfull candidates will have a knowledge in Immunology, and will ideally have extensive expertise in FACS technology and cell biology/molecular biology techniques.

    Please address further queries to :
    Jean-Michel Sallenave
    Professeur d’Immunologie
    ...

  • Poste à pourvoir  : Chargé de projet en écotoxicologie (H/F)

    Catégorie d’emploi  : Agent contractuel de catégorie 2 ou agent titulaire de catégorie A

    Type de contrat  : Contrat à durée indéterminée de droit public, détachement, affectation

    Localisation :  Maisons-Alfort (94)

    Prise de fonction : Dès que possible

    Rémunération selon l’expérience et le niveau de formation par référence aux grilles indiciaires des agences sanitaires, en application du décret n° 2003-224 du 7 mars 2003, ou selon statut particulier si fonctionnaire.

    L’AGENCE ET L’ENTITÉ D’AFFECTATION

    L’Agence nationale de sécurité...

  • The Toulouse Biotechnology Institute (TBI: http://www.toulouse-biotechnology-institute.fr/fr) is an interdisciplinary research laboratory of 320 people. TBI is accredited by both the CNRS and INRAE and develops its research activity at the interface between life sciences and process sciences, covering enzyme discovery and engineering, systems and synthetic biology, fermentation, (bio)chemical engineering, and environmental assessment.
    You will work in the Biocatalysis team headed by Prof Magali-Remaud Simeon in close interaction with a pharmaceutical company to develop enzymatic routes towards bioactive compounds. The position is a full-time, fixed-term position for 12 months, preferably starting in October 2020.

    Job description :
    - Sequence-based search for enzymes
    - Cloning, expression, purification and characterization of several enzymes
    - Determination of kinetic parameters
    - Development of screening assays
    - Improvement of...

  • The Toulouse Biotechnology Institute (TBI: http://www.toulouse-biotechnology-institute.fr/fr) is an interdisciplinary research laboratory of 320 people. TBI is accredited by both the CNRS and INRAE and develops its research activity at the interface between life sciences and process sciences, covering enzyme discovery and engineering, systems and synthetic biology, fermentation, (bio)chemical engineering, and environmental assessment.

    You will work in the Biocatalysis team headed by Prof Magali-Remaud Simeon in close interaction with a pharmaceutical company to develop enzymatic routes towards bioactive compounds. The position is a full-time, fixed-term position for 12 months, preferably starting in October 2020.

    Job description :
    - Sequence-based search for enzymes
    - Cloning, expression, purification and characterization of several enzymes
    - Determination of kinetic parameters
    - Development of screening assays
    - Improv...

  • An ERC-funded Postdoc position is available from Nov 2020 in the Tumor Microenvironment Lab at Institut Curie-Orsay (INSERM U1021, CNRS UMR3347, University Paris-Saclay), in Paris-Orsay in the fields of glioblastoma, neurosurgery and cancer stem cells.

    The institute and the lab
    The Institut Curie Research Center (https://institut-curie.org/profil/researchers) is a world-class multidisciplinary organization created in 1909 by Nobel Laureate Marie Curie bringing together France’s largest center in cancer research and a model hospital group dedicated entirely to the care of cancer patients. The institute is ranked in the top 1% by International Science Index. The scientists of Institut Curie laboratories have access to state-of-art core facilities (https://institut-curie.org/page/platforms).

    The Tumor Microenvironment Lab mainly works on resistance mechanisms in glioblastoma. Glioblastoma is the most deadly type of human cancer. Recurrence is s...

  • Un financement pour une thèse de doctorat (3 ans) est disponible dans l’équipe du Pr J-M Sallenave (‘Equipe 3 : Immunité innée et défenses pulmonaires anti-infectieuses’ ; UMR INSERM 1152, Hôpital Bichat).

    Le projet consistera à étudier la voie IL-6/antimicrobiens/réparation tissulaire dans la mucoviscidose dans des modèles expérimentaux.

    Compétences déjà acquises ou à acquérir :

    - culture cellulaire (cellules immunitaires, cellules épithéliales…)
    - cytométrie en flux, immunohistochimie, immunofluorescence
    - techniques biochimiques (electrophorèse, ELISAs…)
    - techniques de biologie moléculaire (PCR classique, PCR quantitative, clonage…).
    - utilisation de logiciels d’informatique

    Pour tout renseignement, veuillez cont...


Annonces 1 à 9 sur 9


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