Du 05 Octobre 2022 au 05 octobre 2022
Resetting Expectations for CAR-T Potency Assessment – A Novel Target-Cell Killing Based Approach
Horaire : 17h00
Potency assays are an essential aspect of analyses of biotherapeutics, including CAR-T therapeutics. The potency assay format that will be used as a release assay for CTM (in a QC environment) needs to be as accurate, precise and robust as possible.
Developing a robust potency assay for CAR-T therapeutics can be a long and complicated process.
The mechanism of action of CAR-T cells – dubbed ‘living drugs’ – in-vivo is multi-faceted. Currently, target-cell killing and cytokine induction are two of the more prominent measures indicative of CAR-T potency in the cell therapy field.
This webinar will provide the rationale and data that supports transitioning from current interpolation-based cytokine induction assays, with minimal number of dilutions (one), to full-curve analyses based upon MOA-reflective cellular responses.